Lecture by Dr. John Ansley
The SEORL-CCC 2024 National Congress was the scene of an innovative presentation made by the Dr. John Ansley, an otolaryngology specialist at Charleston ENT & Allergy, who presented the results of the 1% clotrimazole otic solution as a treatment for otomycosis, Salvat Laboratories. The conference, entitled «Results of Clotrimazole in the Treatment of Otomycosis», focused on findings from the CLEAR-1 and CLEAR-2 studies, two multicenter Phase 3 clinical trials conducted in the United States, Mexico, and Europe.
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Efficacy and Safety of Clotrimazole Otic
Otomycosis, or fungal ear infection, represents a challenge for specialists due to the limited effectiveness of available antifungal treatments. Dr. Ansley highlighted that the clotrimazole otic solution 1% It is the first approved treatment that specifically addresses otomycosis, surpassing placebo in efficacy in a significant proportion of patients, and also showing high tolerability and low adverse effects.
CLEAR-1 and CLEAR-2 Studies: Demonstration of Therapeutic Cure
The CLEAR-1 and CLEAR-2 trials were conducted to compare the efficacy and safety of otic clotrimazole versus placebo in patients diagnosed with otomycosis. The methodology of both studies included regular visits to assess patient progress and collect fungal culture samples, allowing for the identification of a “therapeutic cure” in those who experienced eradication of the fungus and elimination of symptoms such as pain, itching, and discharge. Clotrimazole 1% demonstrated a cure rate of XNUMX% compared with placebo. 68% vs. 25% placebo, showing significant clinical and statistical results.
Innovation in the Treatment of Fungal Otitis Externa
One of the most innovative aspects of this optical solution is its presentation in Single dose vials and sterile preservative-free solution, which facilitates safe and precise administration, without the need for complex doses that often accompany other topical antifungal treatments.
In conclusion, Dr. Ansley's lecture on the results of 1% clotrimazole otic solution offers ENT specialists a new tool with a high efficacy and safety profile for the treatment of otomycosis. For physicians and health care professionals interested in this and other advances in otolaryngology, SurgSchool provides access to lectures and surgical demonstrations by international experts.
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